Flow Imaging Microscopy Blog

Top 5 Influential FlowCam Papers for Biopharma

FlowCam_8100 w no backgroundThe FlowCam continues to be an important instrument in biopharmaceutical research. The ability to image and characterize morphological features of particulate in parenteral formulations is an important aspect of ensuring quality and safety in injectable drug products.

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Topics: Biopharmaceutical Research, Nanoparticles, FlowCam Technology, Protein Therapeutics

The Value of Flow Imaging in Quality Assurance for Drug Manufacturers

Today’s drug manufacturers are under increasing pressure to understand the particulate composition of their drugs, and to reduce and control particulate in their formulations. To reduce and control particulate matter, manufacturers must first understand its source. Traditionally, particle analysis has been accomplished via light obscuration (LO) and membrane microscopy. While having been the accepted analytical standard methods for particulate composition as outlined by USP <788>, experts have deemed them to be insufficient.

National Institute of Standards and Technology protein standard imaged by the FlowCam. Proteins and non-proteinaceous particles were captured by the FlowCam. 

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Topics: Biopharmaceutical Research, Protein Therapeutics

Detection of Subvisible Particulates in Bioformulations to Ensure Safety

NIST protein standards imaged on the FlowCam Nano at 40XBiopharmaceutical manufacturers strive to ensure patient safety, avoid recalls and protect company reputations. Identifying subvisible particles is an important step in preventing recalls of parenterals. One aspect of product safety is defined in the United States Pharmacopeia (USP) 788 guidelines for particle sizing.  This was designed to control for particles capable of causing capillary occlusion, and therefore focuses on particles larger than 10 µm and 25 µm. As such, no characterization is required for particles below 10 µm. 

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Topics: Biopharmaceutical Research, Nanoparticles, Protein Therapeutics

Technological Advances Push Protein and Particulate Research Further: Insights from the 2018 Workshop on Protein Aggregation and Immunogenicity

KentPetersonCEOFluidImagingTechnologiesKent Peterson is the CEO of Fluid Imaging Technologies.

Every summer, around 160 researchers converge at the Workshop on Protein Aggregation and Immunogenicity hosted in Breckenridge, Colorado by the University of Colorado Center for Pharmaceutical Technology and the AAPS Focus Group on Protein Aggregation and Immunogenicity. 

At the Workshop, scientists studying the behavior, formation, and effects of protein aggregates and other subvisible particles in therapeutic formulations gather to present their research and discuss industry issues.

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Topics: Biopharmaceutical Research, User Spotlight, FlowCam Technology, Protein Therapeutics, News and Events

Japanese Consortium Assesses the Standardization of Flow Imaging Microscopy for Therapeutic Protein Regulations

In a recent study by Kiyoshi et al., a Japanese consortium conducted a collaborative study to assess the standardization of flow imaging microscopy (FIM) for the analysis of subvisible particles (SVPs) and protein aggregates in therapeutic protein products.

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Topics: Biopharmaceutical Research, Protein Therapeutics, User Spotlight

Sub-visible dangers of plastic; nanoparticles in biopharmaceutical devices

Over the years, Fluid Imaging Technologies CEO, Kent Peterson has observed a shift in focus of process components in biopharmaceutical manufacturing from steel and glass to plastic (Single Use Technologies or SUT).  For sure there are advantages and disadvantages of each, from cost to breakage, to formulation interaction and stability.

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Topics: Biopharmaceutical Research, Protein Therapeutics, Nanoparticles

FlowCam Nano Wins Excellence Award at Pittcon 2018


Ten leading edge companies were recognized Tuesday, February 27th with Pittcon Today Excellence Awards at the annual Pittcon Conference and Expo in Orlando, Florida. The award is delivered to new products recognized for ingenuity and innovation in laboratory science.

Fluid Imaging Technologies received the Silver award for the FlowCam Nano and it's Nano-Flow Imaging™ capability.

Pictured at left: Kent Peterson, CEO Fluid Imaging Technologies, Inc. at Pittcon 2018. 

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Topics: Biopharmaceutical Research, FlowCam Technology, Protein Therapeutics

New Flow Imaging Nanoparticle Analyzer Provides Early Warning System of Colloidal Activity for Formulation Scientists

Fluid Imaging to Unveil FlowCam® Nano at Pittcon Booth #1628

Formulation scientists start out with relatively particle free solutions.  Instability may cause precipitation of dissolved matter into colloidal matter. Therefore, the goal of formulation development is to create a stable formulation.  The new FlowCam® provides the submicron images necessary to function as an early warning system of colloidal activity and its origins (protein or silicon oil). The real-time images are invaluable in the identification of the origins of protein aggregation.

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Topics: Biopharmaceutical Research, FlowCam Technology, Protein Therapeutics

PepTalk 2018 - Observations

PepTalk 2018 was held again this January in San Diego, CA with a full week of technical talks, short courses, poster presentations and exhibits. While my perspective centers on protein molecule formulations, I do intersect the industry downstream, where instrumentation is tasked with characterizing drug formulations.

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Topics: Protein Therapeutics, Biopharmaceutical Research

Fluid Imaging Technologies Introduces First Ever Nano-Flow™ Imaging Particle Analyzer

New FlowCam® Nano Ends Biopharmaceutical Dark Ages, Begins Enlightenment.

Scarborough, ME: For the first time ever, Nano-Flow™ particle imaging provides digital images of particles ranging in size from 300nm to 30µm using patented, oil immersion technology for enhanced optical resolution. The new FlowCam® Nano from global laboratory instrumentation manufacturer Fluid Imaging Technologies, Scarborough, ME (www.fluidimaging.com) is the world’s only flow imaging nano particle analyzer.

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Topics: Biopharmaceutical Research, FlowCam Technology, News and Events, Protein Therapeutics