FlowCam® - Flow Imaging Microscopy Blog

Comparing FlowCam Results with Light Obscuration: A Study by Japan's National Institute of Health Sciences

In their recent publication, Quantitative Evaluation of Insoluble Particulate Matters in Therapeutic Protein Injections Using Light Obscuration and Flow Imaging Methods, Shibata et. al. compare the ability of Light Obscuration and Flow Imaging to detect and accurately characterize subvisible particles in injectable drugs.

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Topics: Protein Therapeutics, FlowCam Technology, User Spotlight, Biopharmaceutical Research

FlowCam and the BR1000 Together at BioProcess International Boston

Join us in Boston next week (booth #700) for the BioProcess International conference. This event represents our first combined marketing effort in the Life Sciences sector since our acquisition in 2020.

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Topics: Protein Therapeutics, FlowCam Technology, Biopharmaceutical Research

Top FlowCam Studies for the Biopharmaceutical Industry

Flow Imaging Microscopy is currently recommended by the USP as an orthogonal analytical method for biopharmaceuticals. It has yet to be integrated into every drug development and testing laboratory however. Integrating new technologies upstream in the formulation development process continues to be an essential path for improving the safety and efficiency of the drug development. Once new methods and technologies are proven and accepted upstream, it's possible to pave the way for new technologies to be implemented downstream and beyond. 

Hundreds of biopharmaceutical and pharmaceutical companies worldwide are now using the FlowCam to improve the quality, safety and stability of their formulations. Since most teams purchasing an analytical instrument for their lab want to read studies conducted by other scientists, we have gathered a collection of the top influential studies using the FlowCam to demonstrate how they are integrating Flow Imaging Microscopy into their research.

Top FlowCam Studies for Biopharma

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Topics: Protein Therapeutics, FlowCam Technology, User Spotlight, Biopharmaceutical Research

Morphological Filter Discrimination of Particulates in Injectable Therapeutic Formulations

Pharmaceutical and biopharmaceutical laboratories require rigid characterization of the particulate matter in injectable therapeutics. FlowCam technology offers a benchtop imaging particle analysis tool with unique software features that can discriminate particles based on morphological properties. The data obtained from FlowCam analysis can be used to verify the quality and integrity of parenteral drugs.

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Topics: Protein Therapeutics, Biopharmaceutical Research

FlowCam Used to Study Intravitreal Anti-VEGF Drugs: Particle Burden and Protein Aggregates

In a recent paper discussing particle counting and analytical techniques, the number and type of particles present in intravitreal injection formulations of three different drug agents used against vascular endothelial growth factor were investigated.

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Topics: Protein Therapeutics, Biopharmaceutical Research, Nanoparticles

5 Considerations When Adding Liquid Handling Automation to your Biopharmaceutical Lab

Biopharma labs today are looking for ways to improve accuracy, safety and productivity. The use of robotics to enable the unattended, continuous running of samples is gaining popularity. The following post can help you determine if an automated liquid handling system can help your formulation development lab attain the goals of reproducibility, traceability and flexibility.

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Topics: Industrial Applications, Protein Therapeutics, Biopharmaceutical Research

Bioprocessing Summit in Boston this Week - Discussions on Quality & Stability of Biologics

This week the Bioprocessing Summit is happening in Boston and virtually.

The popular 9th Annual Rapid Methods to Assess Quality & Stability of Biologics conference track will bring together experts in analytical and formulation development to discuss rapid and practical ways to accelerate prediction and screening for protein instabilities in early- and late-stage development. The conference features case studies, unpublished work on new methods and tools employed in real-time and accelerated stability studies for proteins, cell and gene therapy products, high-throughput analytics, developability assessment, high-throughput analytics, multi-attribute methods, post-translational modifications, and stability in vaccines.

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Topics: Protein Therapeutics, User Spotlight, Biopharmaceutical Research

FlowCam Nano Provides Counts, Sizes and Images of Nano- and Microparticles

Application to a therapeutic protein pumping study performed at Skagg School of Pharmacy and Pharmaceutical Sciences

Sub-visible particle characterization is a critical method for assessing drug substance and drug product quality and stability. In this study, we evaluated the capabilities of the new FlowCam Nano (which utilizes patented oil immersion flow microscopy), in conjunction with a peristaltic pumping study that focused on protein particle formation generated during filling pump operations.

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Topics: Protein Therapeutics, FlowCam Technology, User Spotlight, Biopharmaceutical Research, Nanoparticles

FlowCam - Flow Imaging Microscopy (FIM) Guides Forced Degradation of Cell-based Medicinal Products (CBMP)

Cell-based medicinal products (CBMPs) offer promising opportunities for the treatment of diseases with previously limited or no therapeutic options. However, the complexity and intrinsically fragile nature of these CBMPs create significant challenges in formulation development, analytical characterization, manufacturing, and stability assessment.

This recent study used a FlowCam, Flow Imaging Microscope (FIM) assisted by machine learning software, to measure cell viability and concentration, and to quantify debris particulates. These particulates were the result of forced degradation studies that mimic conditions from cell procurement to administration of product. In particular, the effects of freeze-thawing and shaking on CBMPs were studied. Read More

Topics: Protein Therapeutics, Biopharmaceutical Research

Research Paper Uses FlowCam to Study Protein Aggregation in Intravenous Drugs Resulting from External Stressors

There continue to be ongoing concerns about post-manufacture particulate formation in biopharmaceutical drug products. The stresses, which induce particle formation in IV infusion bags, are suspected to be related to the type of diluent (i.e., saline or dextrose).

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Topics: Protein Therapeutics, Biopharmaceutical Research