FlowCam® - Flow Imaging Microscopy Blog

Comparing FlowCam Results with Light Obscuration: A Study by Japan's National Institute of Health Sciences

In their recent publication, Quantitative Evaluation of Insoluble Particulate Matters in Therapeutic Protein Injections Using Light Obscuration and Flow Imaging Methods, Shibata et. al. compare the ability of Light Obscuration and Flow Imaging to detect and accurately characterize subvisible particles in injectable drugs.

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Topics: Protein Therapeutics, FlowCam Technology, User Spotlight, Biopharmaceutical Research

FlowCam with Light Obscuration is Now Available

While analysis with light obscuration is standard, the FDA has long made clear that size data alone, collected with light obscuration, is not adequate to ensure safe and effective drugs. Orthogonal methods such as flow imaging microscopy are necessary to provide validation.

With the FlowCam LO, the first and only light obscuration (LO) instrument with imaging capabilities is now available. This easy-to-use instrument delivers a powerful, all-in-one solution to meet compliance standards while allowing verification with high-resolution images.

Explore our new technology in the video below.

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Topics: News and Events, FlowCam Technology, Biopharmaceutical Research

New FlowCam Technical Notes: Using Preservatives with Phytoplankton Samples

Aquatic scientists often need to store natural samples for a period of time before processing them using FlowCam. There are multiple preservatives available for this purpose. Glutaraldehyde is a
popular choice of preservative because it will preserve pigment autofluorescence, and therefore allows the use of FlowCam's "Trigger Mode" to automatically distinguish cyanobacteria from other algae, and reduce images of detritus and other non fluorescing particles. Another preservative often used is Lugol's solution, which does not preserve fluorescence, but is less toxic and requires less stringent storage conditions.

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Topics: Algae Technology, Marine Research, Freshwater Research, Harmful Algal Blooms, FlowCam Technology, Municipal Water (Drinking/Wastewater), Aquatic Research

FlowCam and the BR1000 Together at BioProcess International Boston

Join us in Boston next week (booth #700) for the BioProcess International conference. This event represents our first combined marketing effort in the Life Sciences sector since our acquisition in 2020.

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Topics: Protein Therapeutics, FlowCam Technology, Biopharmaceutical Research

Top FlowCam Studies for the Biopharmaceutical Industry

Flow Imaging Microscopy is currently recommended by the USP as an orthogonal analytical method for biopharmaceuticals. It has yet to be integrated into every drug development and testing laboratory however. Integrating new technologies upstream in the formulation development process continues to be an essential path for improving the safety and efficiency of the drug development. Once new methods and technologies are proven and accepted upstream, it's possible to pave the way for new technologies to be implemented downstream and beyond. 

Hundreds of biopharmaceutical and pharmaceutical companies worldwide are now using the FlowCam to improve the quality, safety and stability of their formulations. Since most teams purchasing an analytical instrument for their lab want to read studies conducted by other scientists, we have gathered a collection of the top influential studies using the FlowCam to demonstrate how they are integrating Flow Imaging Microscopy into their research.

Top FlowCam Studies for Biopharma

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Topics: Protein Therapeutics, FlowCam Technology, User Spotlight, Biopharmaceutical Research

FlowCam Nano Provides Counts, Sizes and Images of Nano- and Microparticles

Application to a therapeutic protein pumping study performed at Skagg School of Pharmacy and Pharmaceutical Sciences

Sub-visible particle characterization is a critical method for assessing drug substance and drug product quality and stability. In this study, we evaluated the capabilities of the new FlowCam Nano (which utilizes patented oil immersion flow microscopy), in conjunction with a peristaltic pumping study that focused on protein particle formation generated during filling pump operations.

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Topics: Protein Therapeutics, FlowCam Technology, User Spotlight, Biopharmaceutical Research, Nanoparticles

Using FlowCam and Machine Learning to Classify Microcystis at the Genus and Species Levels

The FlowCam was recently used by a team led by Natasha Barteneva of Nazarbayev University to develop a method for the classification of Microcystis colonial morphospecies in samples obtained from a long-term mesocosm experiment (the AQUACOSM Lake Mesocosm Warming Experiment).

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Topics: Freshwater Research, Harmful Algal Blooms, FlowCam Technology, Municipal Water (Drinking/Wastewater), User Spotlight, Aquatic Research

Why Size and Shape Matter: Perspective on the Acquisition of FlowCam by Yokogawa

Yokogawa Fluid Imaging partner, Axel Wilde of ANASYSTA, recently wrote an article discussing the acquisition of Fluid Imaging Technologies by Yokogawa, and how the FlowCam compliments Yokogawa's current product portfolio. Keep reading, or check out the article on Yokogawa's Life Innovation Blog.

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Topics: News and Events, FlowCam Technology

Detecting Subvisible Particles in Protein Therapeutics

Last week, The-Scientist.com introduced their new Research Products blog. Their very first post discusses the capabilities of the FlowCam Nano:

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Topics: Protein Therapeutics, FlowCam Technology, Biopharmaceutical Research, Nanoparticles

2021 FlowCam Aquatic Grant Program is Ready for Launch

The FlowCam Aquatic Research Equipment & Travel Grant is back by popular demand for the 2021-22 academic year. This equipment grant provides an opportunity for one graduate student and up to two undergraduate faculty members to receive the use of a FlowCam for the semester of their choice.

Graduate applicants are eligible for a FlowCam 8000 (8100 or 8400) and undergraduate applicants are eligible for a FlowCam 5000.

Pictured here: Drs. Kerry Whittaker (left) and LeAnn Whitney (right) of Maine Maritime Academy (MMA), winners of the 2020 FlowCam Undergraduate Grant.

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Topics: Marine Research, Freshwater Research, News and Events, Harmful Algal Blooms, FlowCam Technology, Aquatic Research