Fluid Imaging to Unveil FlowCam® Nano at Pittcon Booth #1628
Formulation scientists start out with relatively particle free solutions. Instability may cause precipitation of dissolved matter into colloidal matter. Therefore, the goal of formulation development is to create a stable formulation. The new FlowCam® provides the submicron images necessary to function as an early warning system of colloidal activity and its origins (protein or silicon oil). The real-time images are invaluable in the identification of the origins of protein aggregation.
Ideal for testing therapeutic protein formulations, lyophilized biologics, and all injectable drugs, the FlowCam Nano is the first imaging flow microscope that automatically detects, images and characterizes both micron- and submicron-sized particles in a fluid sample. By understanding how the colloidal stability of different formulations compare, manufacturers are better able to balance efficacy, safety and shelf life to find the ideal formulation that remains stable throughout the process.
To be unveiled at Pittcon 2018 booth #1628 on Feb. 26th in Orlando, Fla., and featured in a technical poster presentation at the conference, the FlowCam Nano enabled Professor John F. Carpenter and Cheng Her, University of Colorado Denver - Anschutz Medical Campus to document differences in particle size distributions in different parenteral drug product formulations. By providing high resolutions images for opaque, transparent, and translucent sub-visible particles and corresponding measurement data using more than 40 different basic and advanced, morphological parameters, the FlowCam Nano led the researchers to conclude the new instrumentation effectively assesses the colloidal stability of drug product formulations.