FlowCam® - Flow Imaging Microscopy Blog

Sarah Isakson

Recent Posts

Austin Water uses FlowCam to Detect Harmful Algal Blooms

Austin Water, the City of Austin, Texas' water utility, recently purchased a FlowCam Cyano instrument. Austin Water first learned about the advantages of flow imaging microscopy from employee Misty Klein (pictured here).

When Misty moved to the City of Austin, she understood that image analysis with FlowCam would be essential to Austin Water's strategy to prevent harmful algal blooms. She recommended FlowCam Cyano to her colleagues and received funding to purchase an instrument in 2021.

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New FlowCam Technical Notes: Using Preservatives with Phytoplankton Samples

Aquatic scientists often need to store natural samples for a period of time before processing them using FlowCam. There are multiple preservatives available for this purpose. Glutaraldehyde is a
popular choice of preservative because it will preserve pigment autofluorescence, and therefore allows the use of FlowCam's "Trigger Mode" to automatically distinguish cyanobacteria from other algae, and reduce images of detritus and other nonfluorescing particles. Another preservative often used is Lugol's solution, which does not preserve fluorescence, but is less toxic and requires less stringent storage conditions.

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Topics: Algae Technology, Marine Research, Freshwater Research, Harmful Algal Blooms, FlowCam Technology, Municipal Water (Drinking/Wastewater), Aquatic Research

FlowCam Used to Study Algae Cultures: Training New Users on Gran Canaria

This week FlowCam Applications Scientist, Kay Johnson, visited the Canary Islands to train a new team of FlowCam users at ITC (Instituto Tecnólogico de Canarias). ITC in Pozo Izquierdo is using a FlowCam 8400 with 488nm laser to monitor marine phytoplankton. The team was originally trained by Nicole Gill when they first purchased the FlowCam in 2019, but this year a new group of scientists from Italy and Serbia have joined their team. 

Pictured here (left to right): Kay Johnson, Flavio Guidi, Tonia Principe, Marianna Venuleo, Maca Golezalaz, Zivan Gojkovic 

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Topics: Industrial Applications, Algae Technology, Marine Research, User Spotlight, Aquaculture, Aquatic Research

Top FlowCam Studies for the Biopharmaceutical Industry

Flow Imaging Microscopy is currently recommended by the USP as an orthogonal analytical method for biopharmaceuticals. It has yet to be integrated into every drug development and testing laboratory however. Integrating new technologies upstream in the formulation development process continues to be an essential path for improving the safety and efficiency of the drug development. Once new methods and technologies are proven and accepted upstream, it's possible to pave the way for new technologies to be implemented downstream and beyond. 

Hundreds of biopharmaceutical and pharmaceutical companies worldwide are now using the FlowCam to improve the quality, safety and stability of their formulations. Since most teams purchasing an analytical instrument for their lab want to read studies conducted by other scientists, we have gathered a collection of the top influential studies using the FlowCam to demonstrate how they are integrating Flow Imaging Microscopy into their research.

Top FlowCam Studies for Biopharma

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Topics: Protein Therapeutics, FlowCam Technology, User Spotlight, Biopharmaceutical Research

Morphological Filter Discrimination of Particulates in Injectable Therapeutic Formulations

Pharmaceutical and biopharmaceutical laboratories require rigid characterization of the particulate matter in injectable therapeutics. FlowCam technology offers a benchtop imaging particle analysis tool with unique software features that can discriminate particles based on morphological properties. The data obtained from FlowCam analysis can be used to verify the quality and integrity of parenteral drugs.

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Topics: Protein Therapeutics, Biopharmaceutical Research

Greater Cincinnati Water Works Uses FlowCam Cyano to Monitor Source Water

Applications Scientist, Kay Johnson has spent this week in Cincinnati training new FlowCam users at the Greater Cincinnati Water Works (GCWW) on their new FlowCam Cyano. GCWW is located on the Ohio River across the water from Kentucky. They will be using the FlowCam Cyano to count and categorize cyanobacteria and other phytoplankton populations both before and after treatment.

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Topics: Harmful Algal Blooms, Municipal Water (Drinking/Wastewater), User Spotlight

FlowCam Nano Provides Counts, Sizes and Images of Nano- and Microparticles

Application to a therapeutic protein pumping study performed at Skagg School of Pharmacy and Pharmaceutical Sciences

Sub-visible particle characterization is a critical method for assessing drug substance and drug product quality and stability. In this study, we evaluated the capabilities of the new FlowCam Nano (which utilizes patented oil immersion flow microscopy), in conjunction with a peristaltic pumping study that focused on protein particle formation generated during filling pump operations.

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Topics: Protein Therapeutics, FlowCam Technology, User Spotlight, Biopharmaceutical Research, Nanoparticles

Welcome Becca, FlowCam Sales Support Specialist

We are happy to welcome Becca Mimmovich to the FlowCam Team. Becca is our new Sales Support Specialist, and she will serve as liaison between our field sales team and the office to streamline the quote generation process and other pre-sales activities.

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Topics: News and Events

Successfully Detecting Algal Blooms with Flow Imaging Microscopy

"After receiving hundreds of complaints, the City of Wichita Falls, Texas, developed a plan for monitoring harmful algal blooms to detect and mitigate taste and odor (T&O) compounds and cyanotoxins."

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Topics: Harmful Algal Blooms, Municipal Water (Drinking/Wastewater), User Spotlight

Using the FlowCam and Machine Learning to Classify Microcystis at the Genus and Species Levels

The FlowCam was recently used by a team led by Natasha Barteneva of Nazarbayev University to develop a method for the classification of Microcystis colonial morphospecies in samples obtained from a long-term mesocosm experiment (the AQUACOSM Lake Mesocosm Warming Experiment).

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Topics: Freshwater Research, Harmful Algal Blooms, FlowCam Technology, Municipal Water (Drinking/Wastewater), User Spotlight, Aquatic Research