Flow Imaging Microscopy Blog

Michelle Devoe

Recent Posts

Baker Hughes Study Demonstrates a New, Quick Method for Produced Water Analysis

A study by Baker Hughes demonstrates that the FlowCam® imaging particle analysis technology is a more informative method than spectrophotometry to evaluate the demulsification of produced water. Produced water generated during oil extraction is held in skim tanks where it is treated with water clarifiers or demulsifiers. Reverse emulsion breakers (REBs) coalesce the oil into larger molecules to be skimmed, or removed, from the produced water. The efficacy of REBs and other water clarifiers on produced water is important because oil extraction companies must meet water quality environmental regulations before releasing produced water back into the environment, or they require a low oil content if the water is to be reused in the extraction process. 

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Topics: Industrial Applications, FlowCam Technology, User Spotlight

We are attending the European Workshop on Protein Aggregation and Immunogenicity

The 4th Annual European Workshop on Protein Aggregation and Immunogenicity will be held in Salzburg-Wals, Austria on January 28 and 29.  This conference serves as a European summit for thought leaders and academic researchers to come together and discuss the issues of protein aggregation and its effects on the immunogenicity of therapeutic protein drug products. We are excited to attend and exhibit the FlowCam imaging particle analyzer with our German distributor, Anasysta.

Proteins and contaminants from a parenteral drug sample, imaged and analyzed by the FlowCam.

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Topics: News and Events, Biopharmaceutical Research, Nanoparticles

FlowCam and VisualSpreadsheet 5.0 Workshop at ASLO Puerto Rico 2019

We will soon be releasing VisualSpreadsheet (ViSP) 5.0, a significant advancement of the FlowCam software.  With ViSP 5.0 you will be able to organize your FlowCam files in a database format, allowing you to analyze multiple runs simultaneously as well as compare and contrast data sets.  This will be especially useful for time-series analyses, longitudinal studies, trend analysis, etc.

    

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Topics: Marine Research, Freshwater Research, News and Events

Biotherapeutic Reformulation Achieved Through Extended Particle Analysis

Proteinaceous particles in parenteral drugs pose an immunogenic risk. These formulations are therefore rigorously characterized for optimal conformational and colloidal stability of the drug molecule. As such, they undergo thorough analysis of biophysical descriptors and extended particle characterization to ensure a safe and stable product is delivered to market with a shelf life of about two years. In this post, we summarize a recent paper by Mattison et al. (2018) published in BioProcess International on how they successfully reformulated biotherapeutics by using quantitative stability predictors and descriptors. 

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Topics: Protein Therapeutics, User Spotlight, Biopharmaceutical Research

Most Popular Flow Imaging Microscopy Blog Posts of 2018

We use our Flow Imaging Microscopy blog as a platform to serve up the latest in relevant news, highlight novel uses of the FlowCam, and announce FlowCam technology developments. This year we blogged about 54 different topics. Below is a recap of the Top 10 Most Read Blog Posts of 2018. 

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Topics: Protein Therapeutics, Marine Research, News and Events, Harmful Algal Blooms, FlowCam Technology, Aquatic Research, Biopharmaceutical Research

Fooled copepods ingest dimethyl sulfide-infused microplastics

December 2018 — Can microplastics be mistaken for algae? A recent study by the University of Plymouth and the Plymouth Marine Laboratory demonstrated that nylon microfibers can acquire dimethyl sulfide (DMS), a compound produced by algae, when environmentally exposed to the compound. The study also showed that Calanus helgolandicus, a chemosensing copepod that uses DMS to locate algae, their normal food source, more readily ingested microplastic fibers infused with DMS (Fig. 1).  The FlowCam was used to enumerate the microplastic fibers and evaluate microplastic fiber uptake during the experiment. 

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Topics: Marine Research, User Spotlight, Aquatic Research

New High-Throughput Method for Elastin-like Polymer (ELP) Coacervate Analysis

December 2018 — A recent study by researchers from the University of New England and University of New Hampshire has demonstrated that flow imaging microscopy is an accurate, more efficient, and more informative method of elastin-like polymer (ELP) coacervate analysis than standard methods. ELP coacervates are a class of molecules with promising applications in drug delivery vehicles, tissue engineering, environmental remediation, and more. ELP coacervate architecture is stimuli-responsive and highly tunable, making them ideal for the above-mentioned applications.  


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Topics: Industrial Applications, User Spotlight, Biopharmaceutical Research, Nanoparticles

Are Blue Mussels the New Microplastic Fiber Sink? A study by Bigelow Lab

December 2018 — Microplastics are an ubiquitous concern for the world's oceans. Increasing demand for consumer plastics has resulted in an estimated 4.8 to 15.11 million metric tons of plastics entering the oceans every year1,2. These macroplastics degrade into microplastics, or plastic fragments <5 mm in diameter, which can range in morphology from rigid pieces to amorphous fibers. 

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Topics: Marine Research, User Spotlight, Aquatic Research

FIT Welcomes Michelle Richards as Newly Hired Buyer

November 2018 — Michelle Richards has joined Fluid Imaging Technologies as the Buyer in supporting production and is excited to be a part of the Fluid Imaging!

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Topics: News and Events

New Method for Meiobenthos Analysis Using FlowCam

Researchers from the Japan Agency for Marine-Earth Science and Technology, and Am-Lab Inc. developed a methodology to use the FlowCam® for analysis of sediment-inhabiting meiobenthos.  

Meiobenthos are small, benthic invertebrates often used as indicators of anthropogenic influence and other natural disturbances. They play a primary role in sediment nutrient cycling and stability in benthic ecosystems. 

Meiobenthos imaged by the FlowCam. Organic matter was stained with Rose Bengal to easily differentiate meiobenthos from inorganic particulates, such as sediment. Imaged organisms are labeled as follows: a) Nematoda; b) Copepoda; c) Nauplius larvae; d) Kinorhyncha; e) Foraminifera. Credit: Kitahashi et al. (2018). 

Optical microscopy, which is labor-intensive and time-consuming, is often the primary technology utilized for analysis of meiobenthos. In this study, Kitahashi et al. developed a method to use the FlowCam and VisualSpreadsheet® for analysis of these small, benthic invertebrates.

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Topics: Marine Research, Freshwater Research, User Spotlight, Aquatic Research