Flow Imaging Microscopy Blog

Cybele Brooks

Recent Posts

Top 5 Influential FlowCam Papers for Biopharma

FlowCam_8100 w no backgroundThe FlowCam continues to be an important instrument in biopharmaceutical research. The ability to image and characterize morphological features of particulate in parenteral formulations is an important aspect of ensuring quality and safety in injectable drug products.

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Topics: Protein Therapeutics, FlowCam Technology, Biopharmaceutical Research, Nanoparticles

The Value of Flow Imaging in Quality Assurance for Drug Manufacturers

Today’s drug manufacturers are under increasing pressure to understand the particulate composition of their drugs, and to reduce and control particulate in their formulations. To reduce and control particulate matter, manufacturers must first understand its source. Traditionally, particle analysis has been accomplished via light obscuration (LO) and membrane microscopy. While having been the accepted analytical standard methods for particulate composition as outlined by USP <788>, experts have deemed them to be insufficient.

National Institute of Standards and Technology protein standard imaged by the FlowCam. Proteins and non-proteinaceous particles were captured by the FlowCam. 

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Topics: Protein Therapeutics, Biopharmaceutical Research

Detection of Subvisible Particulates in Bioformulations to Ensure Safety

NIST protein standards imaged on the FlowCam Nano at 40XBiopharmaceutical manufacturers strive to ensure patient safety, avoid recalls and protect company reputations. Identifying subvisible particles is an important step in preventing recalls of parenterals. One aspect of product safety is defined in the United States Pharmacopeia (USP) 788 guidelines for particle sizing.  This was designed to control for particles capable of causing capillary occlusion, and therefore focuses on particles larger than 10 µm and 25 µm. As such, no characterization is required for particles below 10 µm. 

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Topics: Protein Therapeutics, Biopharmaceutical Research, Nanoparticles

FlowCam Nano Celebrates First Year with Multiple Awards and Recognitions for Innovation

Launched in late 2017, the FlowCam® Nano has garnered several awards and recognitions for breakthrough innovation in laboratory science during its first year on the market. As the only particle analyzer capable of simultaneously counting, characterizing and producing high-resolution digital images of nanoparticles in liquid samples, the FlowCam Nano fills a gap in data procurement and analysis that no other instrument provides.

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Topics: News and Events, FlowCam Technology

$30 Million in New Grant Funding Awarded to Study Harmful Algae Blooms (HABs)

Devastating Red Tide Impacts Coastal Communities of Western Florida

Karenia brevis bloom as imaged by FlowCam. Sample was collected off Sanibel Island in August 2018 by Eric Milbrandt, Director of the Sanibel-Captiva Conservation Foundation, and sent to Fluid Imaging Technologies for analysis. 

This past summer a red tide spread along the Gulf of Mexico shoreline killing millions of fish and threatening human health (not to mention impacting regional tourism).  Harmful algae blooms (HABs) like this occur with regularity nationwide and cost an estimated $50 million each year.

Florida is a Case Study for the Need to Improve HAB Funding

Beyond the problems along the Gulf Coast, southeastern Florida is experiencing a blue-green, cyanobacteria bloom in the St. Lucie River. Recent testing shows that water samples are 10 times too toxic to even touch due to high levels of microcystin, a toxin that can make people and animals sick. Direct contact with the algae can cause a rash.  When ingested, the toxin can cause nausea, vomiting, and in some sever cases, acute liver failure.

To study the effects of HABs and other ocean and Great Lakes pathogens, the National Science Foundation (NSF) and the National Institute of Environmental Health Sciences (NIEHS), one of the National Institutes of Health, have awarded new grants totaling $30 million. The grants fund research on ecosystems in the oceans and in the Great Lakes Basin. 

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Topics: News and Events, Harmful Algal Blooms, Aquatic Research

Celebrating 19 Years in Business with Company-wide Volunteer Day

On September 14th, our team at Fluid Imaging Technologies celebrated its 19th year in business with a day of volunteering at the Maine Audubon Society in Falmouth, Maine. For the past 6 years, the company has dedicated a day of service to celebrate its anniversary. In previous years, we've volunteered our time at The Cape Elizabeth Land Trust, The Royal River Conservation Trust, The Scarborough Land Trust and, The Maine Audubon Society in Scarborough.

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Topics: News and Events

Hands-on FlowCam Workshop in Germany October 1st 2018

We are excited to announce that we will be co-hosting a FlowCam workshop with our European partners Anasysta.  This exclusive introductory workshop on the FlowCam Cyano and the FlowCam 8000 series will be hosted at the University of Konstanz and is scheduled for October 1st, 2018 from 9am - 4pm.

The FlowCam Cyano utilizes a red laser to differentiate cyanobacteria from other algae and detritus in aquatic samples. After capturing digital images of the algae, the FlowCam’s software, VisualSpreadsheet, can be used to further characterize the specific types of all algae found in the sample.

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Topics: Freshwater Research, News and Events, Harmful Algal Blooms, Municipal Water (Drinking/Wastewater)

FlowCam Nano Earns Pharma Innovation Award

We are proud to announce that our FlowCam Nano has earned the Pharmaceutical Manufacturing 2018 Pharma Innovation Award.  Honored in the category of Analytical and Monitoring Devices, the FlowCam Nano particle analyzer is recognized as the industry's first ever flow imaging nano particle analyzer that provides digital images of particles ranging in size from 300 nm to 10+ µm.

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Topics: News and Events, Biopharmaceutical Research, Nanoparticles

Workshop for Cyanobacteria, Phytoplankton and Zooplankton Analysis in Evian France

IAGLR and the European Large Lakes Symposium (ELLS) are co-sponsoring an international conference entitled “Big Lakes, Small World” during the week of September 23-28, 2018 at Lake Geneva in Evian, France. The meeting will be the first IAGLR meeting held outside North America, and in conjunction with the 5th European Large Lakes Symposium.

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Topics: Freshwater Research, Harmful Algal Blooms, Aquatic Research

Oil in water characterization by FlowCam dynamic fluid imaging

In this recently published paper, colleagues at Baker Hughes demonstrated that dynamic fluid imaging can be used to analyze the oil content in produced water. Using the FlowCam, they were able to quickly analyze the oil/solids content, oil droplets size and size distribution using only a small sample size. Additionally, the analysis help to understand the behavior and performance of reverse emulsion breakers (REBs) used in water clarification. As a result, various methods of REBs could be tested and the most effective methods were identified.

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Topics: Industrial Applications, News and Events, FlowCam Technology