FlowCam® - Flow Imaging Microscopy Blog

Cybele Brooks

Recent Posts

FlowCam for the Characterization of Abrasive Compounds

Superabrasives, such as micronized diamonds and cubic boron nitride (CBN), are used extensively in applications for cutting, grinding, and drilling hard materials. The effectiveness of a particular superabrasive material in a given application is largely determined by both particle size and particle shape. 

Above images: Left, mixed diamond powder, particle property shown is Diameter ESD.
Right, high circularity diamond powder particles, filtered by circularity.

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Topics: Industrial Applications, Abrasives

FlowCam with Light Obscuration is Now Available

While analysis with light obscuration is standard, the FDA has long made clear that size data alone, collected with light obscuration, is not adequate to ensure safe and effective drugs. Orthogonal methods such as flow imaging microscopy are necessary to provide validation.

With the FlowCam LO, the first and only light obscuration (LO) instrument with imaging capabilities is now available. This easy-to-use instrument delivers a powerful, all-in-one solution to meet compliance standards while allowing verification with high-resolution images.

Explore our new technology in the video below.

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Topics: News and Events, FlowCam Technology, Biopharmaceutical Research

Yokogawa Fluid Imaging Technologies Named One of 2021 Best Places to Work in Maine

Yokogawa Fluid Imaging Technologies was recently named to the list 2021 Best Places to Work in Maine. The statewide survey and awards program are designed to identify, recognize, and honor the best places of employment in Maine, benefiting the state's economy, its workforce, and businesses.

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Topics: News and Events

FlowCam and the BR1000 Together at BioProcess International Boston

Join us in Boston next week (booth #700) for the BioProcess International conference. This event represents our first combined marketing effort in the Life Sciences sector since our acquisition in 2020.

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Topics: Protein Therapeutics, FlowCam Technology, Biopharmaceutical Research

FlowCam Used to Study Intravitreal Anti-VEGF Drugs: Particle Burden and Protein Aggregates

In a recent paper discussing particle counting and analytical techniques, the number and type of particles present in intravitreal injection formulations of three different drug agents used against vascular endothelial growth factor were investigated.

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Topics: Protein Therapeutics, Biopharmaceutical Research, Nanoparticles

5 Considerations When Adding Liquid Handling Automation to your Biopharmaceutical Lab

Biopharma labs today are looking for ways to improve accuracy, safety and productivity. The use of robotics to enable the unattended, continuous running of samples is gaining popularity. The following post can help you determine if an automated liquid handling system can help your formulation development lab attain the goals of reproducibility, traceability and flexibility.

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Topics: Industrial Applications, Protein Therapeutics, Biopharmaceutical Research

Bioprocessing Summit in Boston this Week - Discussions on Quality & Stability of Biologics

This week the Bioprocessing Summit is happening in Boston and virtually.

The popular 9th Annual Rapid Methods to Assess Quality & Stability of Biologics conference track will bring together experts in analytical and formulation development to discuss rapid and practical ways to accelerate prediction and screening for protein instabilities in early- and late-stage development. The conference features case studies, unpublished work on new methods and tools employed in real-time and accelerated stability studies for proteins, cell and gene therapy products, high-throughput analytics, developability assessment, high-throughput analytics, multi-attribute methods, post-translational modifications, and stability in vaccines.

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Topics: Protein Therapeutics, User Spotlight, Biopharmaceutical Research

FlowCam - Flow Imaging Microscopy (FIM) Guides Forced Degradation of Cell-based Medicinal Products (CBMP)

Cell-based medicinal products (CBMPs) offer promising opportunities for the treatment of diseases with previously limited or no therapeutic options. However, the complexity and intrinsically fragile nature of these CBMPs create significant challenges in formulation development, analytical characterization, manufacturing, and stability assessment.

This recent study used a FlowCam, Flow Imaging Microscope (FIM) assisted by machine learning software, to measure cell viability and concentration, and to quantify debris particulates. These particulates were the result of forced degradation studies that mimic conditions from cell procurement to administration of product. In particular, the effects of freeze-thawing and shaking on CBMPs were studied. Read More

Topics: Protein Therapeutics, Biopharmaceutical Research

FlowCam at the National Marine Educators Association (NMEA) Conference

Earlier this month, Savannah Judge, one of our Aquatic Markets Experts, co-presented with Kerry Whittaker and LeAnn Whitney of The Corning School of Ocean Studies at Maine Maritime Academy in Castine, ME. The topic of the presentation was "Use of high-throughput fluid imaging technology in the field-based undergraduate ocean classroom with FlowCam".

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Topics: Marine Research, News and Events, User Spotlight, Aquatic Research

Research Paper Uses FlowCam to Study Protein Aggregation in Intravenous Drugs Resulting from External Stressors

There continue to be ongoing concerns about post-manufacture particulate formation in biopharmaceutical drug products. The stresses, which induce particle formation in IV infusion bags, are suspected to be related to the type of diluent (i.e., saline or dextrose).

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Topics: Protein Therapeutics, Biopharmaceutical Research