Flow Imaging Microscopy Blog

What Does "Orthogonal Method" Mean for Particle Analysis?

Comprehensive characterization of proteins is often challenging given their complexity. In many cases, singular analytical methods cannot provide the complete picture for specific attributes. Orthogonal methods—different methods intended to measure similar attributes—are often necessary to provide independent confirmation of protein properties. 

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Topics: News and Events, Biopharmaceutical Research

Fluorescent Photopigments Captured with Trigger Mode at the University of Algarve

The FlowCam's "trigger-mode" enables the user to capture individual images of excited, fluorescing particles every time one passes the camera. Cyanobacteria and Cryptophyta contain the photopigments chlorophyll and phycobiliproteins.  These photopigments can be excited using a FlowCam equipped with a 532 nm laser. When the FlowCam is set to "trigger-mode", each fluorescing particle that passes the camera view "triggers" the FlowCam to capture its image.

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Topics: FlowCam Technology, User Spotlight, Aquatic Research

Semi-automated method for detecting and counting cells of cyanobacterial colonies and filaments


Microcystis & AnabaenaAt the upcoming 2nd Interdisciplinary Freshwater Harmful Algal Blooms (IFHAB) Workshop in Toronto, Ontario (April 16-18) our very own Frances Buerkens will present a session on how the FlowCam was used by scientists from the California department of Water Resources to estimate cell abundance of colonial Microcystis.
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Topics: Freshwater Research, News and Events, Harmful Algal Blooms

Optical System Images Nanoparticles in Biopharmaceuticals 


Measuring and monitoring particulate matter present in injectable drugs is extremely important to companies involved in formulation development, manufacturing and packaging. Adverse effects caused by visible and subvisible particles have been well- documented over the years.  The risks range from reduced efficacy to significant immunogenic responses. 

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Topics: News and Events, FlowCam Technology, Biopharmaceutical Research

Printer Toner to Cosmetics: 2018 Particle Analysis Services Report

Fluid Imaging Technologies' Particle Analysis Services receives a wide variety of particles for analysis on the FlowCam. In the first three months of 2018, our Particle Analysis Services have analyzed numerous samples from printer toner, to bacteria, to cosmetic powders. The full list of samples submitted to our Particle Analysis Services  in 2018 follows:

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Topics: News and Events

Local FlowCam Services in 20+ Countries

FlowCam services are provided world-wide. Countries with technically trained FlowCam sales, support and service representatives are highlighted in blue. 

The Technical Customer Support team at Fluid Imaging Technologies travels world-wide to provide training and support to FlowCam users. In addition to our in-house services, Fluid Imaging Technologies also partners with technical experts in 20+ countries to train and support FlowCam users locally. Some are dealer reps while others are factory trained to provide a full suite of services. We are proud to provide regional services to eliminate language barriers and provide local, economical services to our global user-community. Examples of local services that may be available include: training, IQ/OQ, preventative maintenance, upgrades and repairs.

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Topics: News and Events

Welcome to Fluid Imaging Technologies, Alex Ensign! 

In February 2018, Alex Ensign was hired as our newest Mechanical Engineer. He will be involved in the design and development of the FlowCam. 

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Topics: News and Events

Boogieing Around Maine for Green Crab Larvae  

During the summer of 2017, UNE student Ariella Danzinger worked to develop a prototype for a remote-controlled zooplankton collection device. Her mentor, Dr. Markus Frederich, Professor of Marine Sciences at the University of New England (UNE), studies the invasive green crab and its response to climate change. Next in Frederich's line of research is to better understand the green crab during its larval stage. 

UNE student Ariella Danzinger with her zooplankton suction and collection device, which was used to collect green crab larvae samples during a summer study with Dr. Markus Frederich. Credit: University of New England.

"We know by now in great detail what kind of adult invasive crabs come here, when they breed, how fast they grow, and more. But we don’t know much about the larvae populations in this area," says Frederich. 

The collection of green crab larvae and other zooplankton samples can be thwarted by water that is too deep for the researcher to wade in or by water too shallow for a boat to tow a plankton net.  Danzinger spent her summer working in Frederich's lab developing a remote plankton suction and collection device, affectionately termed the "sucker", to solve the zooplankton collection gap. 

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Topics: User Spotlight, Aquatic Research

FlowCam Nano Wins Excellence Award at Pittcon 2018


Ten leading edge companies were recognized Tuesday, February 27th with Pittcon Today Excellence Awards at the annual Pittcon Conference and Expo in Orlando, Florida. The award is delivered to new products recognized for ingenuity and innovation in laboratory science.

Fluid Imaging Technologies received the Silver award for the FlowCam Nano and it's Nano-Flow Imaging™ capability.

Pictured at left: Kent Peterson, CEO Fluid Imaging Technologies, Inc. at Pittcon 2018. 

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Topics: Protein Therapeutics, FlowCam Technology, Biopharmaceutical Research

New Flow Imaging Nanoparticle Analyzer Provides Early Warning System of Colloidal Activity for Formulation Scientists

Fluid Imaging to Unveil FlowCam® Nano at Pittcon Booth #1628

Formulation scientists start out with relatively particle free solutions.  Instability may cause precipitation of dissolved matter into colloidal matter. Therefore, the goal of formulation development is to create a stable formulation.  The new FlowCam® provides the submicron images necessary to function as an early warning system of colloidal activity and its origins (protein or silicon oil). The real-time images are invaluable in the identification of the origins of protein aggregation.

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Topics: Protein Therapeutics, FlowCam Technology, Biopharmaceutical Research