Dynamic Imaging Particle Analysis Blog

Students from coast to coast learn about imaging particle analysis

Originally developed at the Bigelow Laboratory for Oceanographic Sciences in Boothbay Harbor, Maine, the FlowCam® technology was one of the first to combine the capabilities of a flow cytometer with a digital imaging microscope in order to make plankton identification quicker and easier. Today, the FlowCam is an accepted aquatics research tool in the laboratory and students from coast to coast are learning how it can help them in their studies.

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Topics: Marine Algae, Dynamic Imaging Particle Analysis, Aquatic Research

A closer look at dynamic imaging particle analysis

It’s no surprise that there are many technologies available to analyze subvisible particles. Particle sizing and characterization are critical components of many processes across a wide range of applications.  For example:

  • Municipalities monitor drinking water supplies to detect and quantify taste and odor causing algae.
  • Pharmaceutical companies analyze particles in parenteral drug formulations to help ensure its efficacy and safety.
  • Food and beverage companies use particle analysis to control the quality of their ingredients and end product.
  • Ocean researchers use particle analysis to study and document microscopic life in the earth’s oceans.

The list could go on and on...

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See our new dynamic imaging particle analysis instruments at Pittcon

We're excited to be launching two new products at Pittcon 2015 this week, FlowCam® Biologics and FlowCam® Macro.

FlowCam Biologics

Using the proven industry-leading image quality found in the FlowCam VS-Series, FlowCam Biologics is a dynamic imaging particle analysis (DIPA) system completely optimized for the analysis of sub-visible particulates in protein therapeutics.

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Topics: Industrial Applications, Protein Therapeutics, Food & Beverage Applications

Ensuring Optimal Particle Analysis Results with Protein Samples

By Ben Spaulding, Laboratory Manager

In the pharmaceutical industry, there are many regulations and standards that are imposed on products and processes. Among these are U.S. Pharmacopeia Convention 788 Standard (Particulate Matter in Injections) and the U.S. Food & Drug Administration CFR Title 21 Part 211 (Current Good Manufacturing Practice for Finished Pharmaceuticals). The former standard can play a key role in biochemistry, assay, and formulations departments in both minor and major pharmaceutical companies.

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Topics: Protein Therapeutics, Particle Analysis Lab

We've selected our 2014 Algae Technology Research Grant Recipient

We've awarded our 2014 Algae Technology Research Grant to Coral J. Fung Shek, M.S.E. Candidate, Department of Chemical and Biomolecular Engineering, Johns Hopkins University. Her proposal, Design and Establishment of Artificial Lichens for Biofuels, was selected after a series of in-depth reviews by a panel of independent industry experts in the Algae Technology field. Congratulations, Coral!

Judging criteria included scientific merit, appropriate use of the FlowCam® and the ability to obtain measurable results during a research period of four months. 

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Topics: Algae Technology

Imaging particle analysis helps phytoplankton diversity studies

Joaquim_GoesJoaquim Goes is a Research Professor at Columbia University in the Department of Marine Biology and Paleo Environment at Lamont-Doherty Earth Observatory. He’s a biological oceanographer with interests spanning from phytoplankton cellular biochemistry to large-scale oceanographic processes. A recent example of his work is from the Arabian Sea, where he began observing massive outbreaks of algal blooms during the winter monsoon. Goes and his colleagues, in collaboration with a team of scientists in India, were able to report that these blooms were taxonomically unlike any bloom species reported before and that their appearance every year was causing a loss of phytoplankton diversity. With the help of shipboard and laboratory experiments, they were able to find out that the spread of low oxygen into the upper sun lit layers of the Arabian Sea was causing these blooms.

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Topics: Aquatic Research

Particle characterization helps deliver uniform carbon nanotube products to customers

Carbon nanotubes (CNTs) are low density, flexible, electrically conductive materials, with individual tubes having relatively high tensile strength. Nanocomp Technologies, Inc. produces carbon nanotubes in the form of sheets, tapes, powders, dispersions, and yarns. Their products are used for aerospace, aviation, armor, and flame-resistant applications.
Nanocomp’s CNTs have tremendous aspect ratios; thousands of times greater than other commercially available carbon nanotubes. 

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Topics: Industrial Applications

Studying copepods and phaeocystis to understand climate and food webs

Hans H. Jakobsen, Ph.D is a senior researcher in the Department of Bioscience, Marine Diversity and Experimental Ecology at Aarhus University in Denmark. His list of published papers and articles is extensive and impressive. 

Studying Copepods

Much of Dr. Jakobsen’s work involves the study of grazer interaction among plankton organisms. He’s about to start a small project with his colleagues at neighboring Roskilde University where they will follow the dynamics in copepod rearing tanks. 

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Topics: Algae Research, Marine Algae, Oceanographic Research, Aquatic Research

How Sensitivity Can Impact Protein Aggregate Characterization

When performing sub-visible particle analysis of protein therapeutics, you need to be able to separate protein aggregates from silicone droplets and other contaminants. The ability to properly identify and enumerate protein aggregates, especially in the 2 to 10 micron range, is of utmost importance.

One challenge with protein aggregate characterization stems from their semi-transparency. For this reason, they are often mis-characterized or not even seen by light obscuration systems.

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Topics: Protein Therapeutics

Technologies for plankton identification and monitoring

A recent article in ECO Magazine by Kira Coley of Planet Ocean provides a great overview of what’s happening in the world of plankton identification and monitoring technologies, especially how it relates to climate change. Thanks to many new advances, there’s now a suite of automated technology aimed at observing and measuring plankton in real time, from both above and below the surface waters.

Researchers have found that rising temperatures in the world’s oceans will affect carbon cycles as well as the abundance and function of the plankton on which most marine life feeds. Monitoring long-term variability of planktonic communities can also strengthen ecosystem response models.

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Topics: Algae Research, Marine Algae, Oceanographic Research, Aquatic Research